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|
Cell line
|
Group
|
Cell survival rate (%)
|
p
|
|---|
| | |
Control
|
GCV(5 ug/ml)
|
5-Fc(100 ug/ml)
|
GCV(5 ug/ml)+ 5-Fc(100 ug/ml)
| |
|---|
|
HepG2
|
HepG2
|
97 ± 5
|
96 ± 3
|
99 ± 1
|
95 ± 2
|
0.16
|
| |
HepG2-Vector
|
100 ± 3
|
97 ± 3
|
98 ± 1
|
99 ± 3
|
0.38
|
| |
HepG2-CDglyTK
|
99 ± 3
|
97 ± 6
|
94 ± 5
|
96 ± 3
|
0.57
|
| |
p
|
0.201
|
0.17
|
0.13
|
0.20
| |
|
L9981
|
L9981
|
96 ± 3
|
94 ± 2
|
95 ± 6
|
94 ± 4
|
0.08
|
| |
L9981-Vector
|
94 ± 3
|
95 ± 3
|
97 ± 5
|
95 ± 3
|
0.09
|
| |
L9981-CDglyTK
|
94 ± 5
|
67 ± 2
|
71 ± 4
|
34 ± 3
|
0.01
|
| |
P
|
0.32
|
0.002
|
0.0025
|
0.0021
| |
|
NL9980
|
NL9980
|
96 ± 1
|
96 ± 3
|
95 ± 2
|
97 ± 4
|
0.1
|
| |
NL9980-Vector
|
93 ± 3
|
94 ± 2
|
95 ± 4
|
95 ± 3
|
0.11
|
| |
NL9980-CDglyTK
|
96 ± 5
|
63 ± 1
|
66 ± 5
|
36 ± 4
|
0.00
|
| |
P
|
0.22
|
0.03
|
0.011
|
0.00
| |
- The MTT method was used to determine cellular viability. 5-Fc and/or GCV treatment significantly decreased the cellular survival rate in L9981 cells with CD and TK transgenes. The cells treated with 5-Fc and GCV together showed the maximal reduction.
